Redox and Peroxidase Activities of the Hemoglobin Superfamily: Relevance to Health and Disease

摘要: Abstract Significance: Erythrocyte hemoglobin (Hb) and myocyte myoglobin, although primarily oxygen-carrying proteins, have the capacity to do redox chemistry. Such activity in wider family of globins now appears important associations with mechanisms cell stress response. In turn, an understanding such vivo may a potential cancer therapy resistance neurodegenerative disorders as Alzheimer's. Recent Advances: There has been enhanced chemistry globin superfamily recent years, leading advances development Hb-based blood substitutes hypotheses relating specific disease mechanisms. Neuroglobin (Ngb) cytoglobin (Cygb) linked protection against hypoxia oxidative stress, implications onset progression diseases for Ngb Cygb. Critical Issues: Despite c...