Deciphering Signatures of Mutational Processes Operative in Human Cancer

作者: Ludmil B. Alexandrov , Serena Nik-Zainal , David C. Wedge , Peter J. Campbell , Michael R. Stratton

DOI: 10.1016/J.CELREP.2012.12.008

关键词: Computational biologyGeneticsExomeMechanism (biology)MutationBiologyHuman genomeGenomeLineage (genetic)KataegisCancer

摘要: … In this study, a signature of a mutational process is represented as a discrete probability density function with a domain of preselected mutation features. Mathematically, …

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