Anti-inflammatory effect of Rhus verniviflua Stokes by suppression of iNOS-mediated Akt and ERK pathways: in-vitro and in-vivo studies.
作者： Chang Hwa Jung , Jeong-Hyun Kim , Ji Hye Kim , Joo Hee Chung , Han-Seok Choi
DOI: 10.1111/J.2042-7158.2011.01251.X
关键词: In vivo 、 Nitric oxide 、 MAPK/ERK pathway 、 Signal transduction 、 Pharmacology 、 Protein kinase B 、 Kinase 、 Nitric oxide synthase 、 Biochemistry 、 Anti-inflammatory 、 Chemistry
摘要: Objectives Rhus verniciflua Stokes (RVS), which has valuable medicinal properties, for many years been prescribed inflammation in east Asian medicine. Recent studies suggest that RVS potent antioxidative, antitumor and anti-inflammatory properties. Methods In this study, the effects of vitro vivo were investigated. The ethanol extract from was partitioned with different solvents order increasing polarity. Key findings Among various extracts, n-butanol displayed most activity against nitric oxide reactive oxygen species. also significantly regulates expression synthase, inhibits production at transcriptional level activated macrophages. Immunoblot analysis showed suppresses phosphorylation extracellular signal-regulated kinase Akt, suggesting synthase suppression might be mediated via Akt signaling pathways. This study investigated whether exerts an effect animal model. reduces carrageenan-induced mouse paw edema 5 h. Conclusions These results could a promising candidate agent prevention combination therapy drugs.
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