Neuroblasts of the postnatal mammalian forebrain: Their phenotype and fate

摘要: The subventricular zone (SVZ) is the only germinal of developing mammalian forebrain to persist postnatally. Although SVZ has been known give rise most glial cells forebrain, several studies over past few years have shown that neonatal and adult can also generate neurons. Recent demonstrated a discrete region anterior part composed exclusively neuronal progenitor cells, whose progeny become interneurons olfactory bulb. This review will explore properties distinguish this segment (SVZa) from more posterior, gliogenic region. SVZa, as well its extension forming rostral migratory stream enters middle bulb, antigenic characteristics phenotype, yet continue divide during migration. In vitro, SVZa retain phenotype despite persistent division. Intriguingly, their migrate long distances along highly stereotypical pathway. To better understand guidance cues used by SVZa-derived migration, both homotopic heterotopic transplantation experiments conducted. homotopically transplanted into another animal's with recipient's endogenous in an indistinguishable manner, whereas those embryonic telencephalic ventricular zone, normally destined follow radial glia cerebral cortex, fail following SVZa. heterotopically striatum were able disperse site implantation. Thus, are special proliferating for which particularly permissive