HSL Attenuates the Follicular Oxidative Stress and Enhances the Hair Growth in ob/ob Mice

摘要: Alopecia markedly reduces a patient’s quality of life1 and is thus an important topic in nursing science. Administrations minoxidil finasteride are the most established treatments for androgenetic alopecia at present.2,3 However, their efficacy varies among individuals,4 suggesting that some intrinsic factors affect pathology and/or treatment alopecia. Recently, researchers have identified association between metabolic syndrome (MS).5 We other shown elevated oxidative stress skin patients with MS6–8 scalp areata.9 Furthermore, reduced activity paraoxonases (PONs, antioxidant enzymes) has been areata.10 Therefore, we hypothesized administration substrate PONs would attenuate enhance progression hair cycle MS model mice. In this study, demonstrated promoting effects N-(3-oxododecanoyl)-l-homoserine lactone (HSL), PONs, applied topically to back ob/ob mice on growth through attenuation stress.