Characterization of submicron polyethylene wear debris from synovial-fluid samples of revised knee replacements using a light-scattering technique.
作者： David W. Hahn , Debra L. Wolfarth , Nancy L. Parks
DOI: 10.1002/(SICI)1097-4636(199607)31:3<355::AID-JBM9>3.0.CO;2-L
关键词: Volume fraction 、 Synovial fluid 、 Surgery 、 Implant 、 Particle 、 Materials science 、 Biomedical engineering 、 Light scattering 、 Biocompatibility 、 Polyethylene 、 Biomaterial
摘要: The objectives of this study were to determine whether submicron-sized ultra-high-molecular-weight polyethylene (UHMWPE) wear debris was present in synovial fluid surrounding knee implants, and report on the utility a light-scattering technique for situ analysis debris. measured coefficients implant samples significantly larger than control (p < 0.0001). enhanced light scattering attributed presence submicron UHMWPE particles. This is consistent with considerations Raman spectroscopy survey fluid. mean particle volume fraction 1.11 x 10(-5) cm3/mL six samples, diameters range 200-300 nm. fractions found differ by factor 2 between osteolytic nonosteolytic cases. current findings warrant further work role mechanisms biomaterials development osteolysis following total replacement.
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