Examination of lacZ mutant induction in the liver and testis of Muta Mouse following injection of halogenated aliphatic hydrocarbons classified as human carcinogens.
作者： Noriyuki HACHIYA , Yutaka MOTOHASHI
关键词: 1,2-Dibromoethane 、 Molecular biology 、 Genetically modified mouse 、 Gene mutation 、 Mutation 、 Carcinogen 、 Mutant 、 Chemistry 、 Biochemistry 、 Carbon tetrachloride 、 1,2-Dibromo-3-chloropropane
摘要: Possible induction of lacZ mutation was examined in the liver and testis Muta™Mouse following administration carcinogenic halogenated compounds, namely 1, 2-dichloroethane (DCE), 2-dibromoethane (DBE), carbon tetrachloride, or 2-dibromo-3-chloropropane (DBCP). Slight increases were observed on mutant frequency DNA isolated from mice 14 days after treatment with DBCP at 40 mg/kg DBE 60 but not liver. Further investigation necessary to confirm by these chemicals including experiments longer sampling intervals. No increase detected DCE single doses up 150 consecutive injections 280 mg/kg. Marginal biologically insignificant responses tetrachloride exposed mice. The present results suggest that are less efficient for gene Muta™Mouse.
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