Ethylene dibromide: negative results with the mouse dominant lethal assay and the electrophoretic specific-locus test
作者： L.B. Barnett , D.P. Lovell , C.F. Felton , B.J. Gibson , R.R. Cobb
DOI: 10.1016/0165-7992(92)90085-V
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摘要: Abstract Ethylene dibromide (1,2-dibromoethane; EDB) was tested for the induction of dominant lethal and electrophoretically-detectable specific-locus mutations in germ cells DBA/2J male mice. Males were treated with a single intraperitoneal injection 100 mg/kg EDB mated to two C57BL/6J females. In assay, matings carried out measure effect on meiotic postmeiotic stages; representing spermatogonial stem analyzed electrophoretic test. Neither these cell tests produced any evidence that is mutagen. It appears from data those reported literature EDB, genotoxic carcinogen affects fertility some mammalian species, not mutagenic mouse.
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Yasuhiko Shirasu, Masaaki Moriya, Hideo Tezuka, Shoji Teramoto, Toshihiro Ohta, Tatsuo Inoue, Mutagenicity of Pesticides Springer, Boston, MA. pp. 617- 624 ,(1984) , 10.1007/978-1-4613-2399-0_28
K. Edwards, H. Jackson, A.R. Jones, Studies with alkylating esters—II: A chemical interpretation through metabolic studies of the antifertility effects of ethylene dimethanesulphonate and ethylene dibromide Biochemical Pharmacology. ,vol. 19, pp. 1783- 1789 ,(1970) , 10.1016/0006-2952(70)90171-1
P.G. Kale, J.W. Baum, Sensitivity of Drosophila melanogaster to low concentrations of gaseous mutagens. II. Chronic exposures. Mutation Research. ,vol. 68, pp. 59- 68 ,(1979) , 10.1016/0165-1218(79)90078-8
R. Wayne Hendren, G. T. Roberts, Fred Chasalow, F. M. Johnson, Ann Morgan, Ruth Zweidinger, R. K. Sharma, Susan E. Lewis, The detection of mutants in mice by electrophoresis: results of a model induction experiment with procarbazine. Genetics. ,vol. 97, pp. 113- 124 ,(1981) , 10.1093/GENETICS/97.1.113
I.-D. Adler, A review of the coordinated research effort on the comparison of test systems for the detection of mutagenic effects, sponsored by the E.E.C. Mutation Research\/environmental Mutagenesis and Related Subjects. ,vol. 74, pp. 77- 93 ,(1980) , 10.1016/0165-1161(80)90234-4
D. AMIR, The sites of the spermicidal action of ethylene dibromide in bulls. Reproduction. ,vol. 35, pp. 519- 525 ,(1973) , 10.1530/JRF.0.0350519
G. T. Roberts, F. M. Johnson, H. V. Mailing, R. K. Sharma, Action of N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide hydrochloride (procarbazine hydrochloride) in the germ tissue of mice: dominant lethal effects. Archives of Toxicology. ,vol. 41, pp. 287- 294 ,(1979) , 10.1007/BF00296898
J E Huff, 1,2-Dibromoethane (ethylene dibromide). Environmental Health Perspectives. ,vol. 47, pp. 359- 363 ,(1983) , 10.1289/EHP.8347359
G. Krishna, J. Xu, J. Nath, M. Petersen, T. Ong, In vivo cytogenetic studies on mice exposed to ethylene dibromide. Mutation Research\/genetic Toxicology. ,vol. 158, pp. 81- 87 ,(1985) , 10.1016/0165-1218(85)90101-6
Samuel S. Epstein, Elsie Arnold, Joan Andrea, Willa Bass, Yvonne Bishop, Detection of chemical mutagens by the dominant lethal assay in the mouse. Toxicology and Applied Pharmacology. ,vol. 23, pp. 288- 325 ,(1972) , 10.1016/0041-008X(72)90192-5