A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production

作者: Laura J Simpson , Sana Patel , Nirav R Bhakta , David F Choy , Hans D Brightbill

DOI: 10.1038/NI.3026

关键词: ImmunologyInflammationmicroRNABiologyIL-2 receptorGene expressionInterleukin 13Downregulation and upregulationCell biologyCytotoxic T cellCellular differentiation

摘要: miRNAs 'tune' gene expression to orchestrate cell activity. Ansel and colleagues show that miR-19 modulates TH2 cytokine production by targeting TH2-specific as well general T cell–activation pathways.

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