Cochleotopic selectivity of a multichannel scala tympani electrode array using the 2-deoxyglucose technique

摘要: Abstract The 2-deoxyglucose (2-DG) technique was used to study the cochleotopic selectivity of a multichannel scala tympani electrode array in four cats with another acting as an unstimulated control. Each animal unilaterally deafened and inserted 6 mm into tympani. Thresholds electrical stimulation were determined by recording electrically evoked auditory brainstem responses (EABRs). injected 2-DG, stimulated using bipolar electrodes located either distal or proximal round window. contralateral ear acoustic tone pips at frequencies that matched place. Stimulation both 3 x EABR threshold, localized 2-DG labelling ipsilateral cochlear nucleus (CN) inferior colliculus (IC), which very similar orientation breadth pips. position 24–26 kHz region each structure, whereas around 12 kHz. Distal 10x threshold produced broad IC centered present results clearly illustrate electrodes. extent this is dependent on stimulus levels. has great potential evaluating efficacy new designs.