Comparison of the effect of reduced-fluence photodynamic therapy with intravitreal bevacizumab and standard-fluence alone for polypoidal choroidal vasculopathy.
作者： Nai-Wen Fan , Ling-Ing Lau , Shih-Jen Chen , Chang-Sue Yang , Fenq-Lih Lee
DOI: 10.1016/J.JCMA.2013.10.012
关键词: Retrospective review 、 Intravitreal bevacizumab 、 Ophthalmology 、 Surgery 、 Visual acuity 、 After treatment 、 Treatment protocol 、 Medicine 、 Combination therapy 、 Photodynamic therapy 、 Increased lipid
摘要: Abstract Background Photodynamic therapy (PDT) has previously been reported to be effective in treating polypoidal choroidal vasculopathy (PCV), with satisfactory polyp regression. However, the optimum treatment protocol remains controversial. This study compared effect of reduced-fluence PDT combined intravitreal bevacizumab (rPDT/IVB) and standard-fluence (sPDT) alone for symptomatic PCV Chinese patients. Methods A retrospective review was carried out medical records patients who were treated rPDT/IVB (14 eyes 13 patients) or sPDT (12 12 at least 6 months follow-up. Results The mean best-corrected visual acuity group improved significantly 6-month follow-up ( p = 0.041). Only one eye (7.1%) showed a decrease acuity, four (33.3%) group. total 40.0% increased lipid exudate 1 month after treatment, whereas no increase observed = 0.015). maximum area post-treatment hemorrhage smaller than that (2.57 ± 2.74 mm 2 vs. 12.69 ± 10.28 mm , = 0.042). Conclusion Combination encouraging results vision improvement, lower less sPDT.
core.ac.uk
sci-hub.se 参考文章(35)
Ursula Schmidt-Erfurth, Irene Barbazetto, Stephan Michels, Horst Laqua, Photodynamic effects on choroidal neovascularization and physiological choroid. Investigative Ophthalmology & Visual Science. ,vol. 43, pp. 830- 841 ,(2002)
Wai-Man Chan, Dennis S.C Lam, Timothy Y.Y Lai, David T.L Liu, Kenneth K.W Li, Yi Yao, Tak-Hung Wong, Photodynamic therapy with verteporfin for symptomatic polypoidal choroidal vasculopathy: One-year results of a prospective case series Ophthalmology. ,vol. 111, pp. 1576- 1584 ,(2004) , 10.1016/J.OPHTHA.2003.12.056
Chung-hua i hsüeh hui, Journal of the Chinese Medical Association : JCMA Chinese Medical Association. ,(2003)
Ursula Schlötzer-Schrehard, Ursula Schmidt-Erfurth, Arne Viestenz, Gottfried O. H. Naumann, Horst Laqua, Histopathological changes following photodynamic therapy in human eyes. Archives of Ophthalmology. ,vol. 120, pp. 835- 844 ,(2002)
Masanobu Uyama, Mitsumasa Wada, Yoshimi Nagai, Takashi Matsubara, Hiroshi Matsunaga, Ichiro Fukushima, Kanji Takahashi, Miyo Matsumura, Polypoidal choroidal vasculopathy: natural history. American Journal of Ophthalmology. ,vol. 133, pp. 639- 648 ,(2002) , 10.1016/S0002-9394(02)01404-6
Fumi Gomi, Masahito Ohji, Kaori Sayanagi, Miki Sawa, Hirokazu Sakaguchi, Yusuke Oshima, Yasushi Ikuno, Yasuo Tano, One-Year Outcomes of Photodynamic Therapy in Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in Japanese Patients Ophthalmology. ,vol. 115, pp. 141- 146 ,(2008) , 10.1016/J.OPHTHA.2007.02.031
Ursula Schmidt-Erfurth, Christopher Kiss, Stefan Sacu, The role of choroidal hypoperfusion associated with photodynamic therapy in neovascular age-related macular degeneration and the consequences for combination strategies. Progress in Retinal and Eye Research. ,vol. 28, pp. 145- 154 ,(2009) , 10.1016/J.PRETEYERES.2009.01.001
Stephan Michels, Fabian Hansmann, Wolfgang Geitzenauer, Ursula Schmidt-Erfurth, Influence of treatment parameters on selectivity of verteporfin therapy. Investigative Ophthalmology & Visual Science. ,vol. 47, pp. 371- 376 ,(2006) , 10.1167/IOVS.05-0354
Sung Chul Lee, Youl Seok Seong, Sung Soo Kim, Hyung Jun Koh, Oh Woong Kwon, Photodynamic therapy with verteporfin for polypoidal choroidal vasculopathy of the macula. Ophthalmologica. ,vol. 218, pp. 193- 201 ,(2004) , 10.1159/000076844
Y Mitamura, M Kubota-Taniai, K Okada, M Kitahashi, T Baba, S Mizunoya, S Yamamoto, Comparison of photodynamic therapy to transpupillary thermotherapy for polypoidal choroidal vasculopathy. Eye. ,vol. 23, pp. 67- 72 ,(2009) , 10.1038/SJ.EYE.6702996