Norepinephrine increases cardiac preload and reduces preload dependency assessed by passive leg raising in septic shock patients.

作者: Xavier Monnet , Julien Jabot , Julien Maizel , Christian Richard , Jean-Louis Teboul

DOI: 10.1097/CCM.0B013E318206D2A3

关键词: Cardiac indexAnesthesiaNorepinephrine (medication)PreloadShock (circulatory)ResuscitationCatecholamineSeptic shockMedicineIntensive care

摘要: Objective:To assess the effects of norepinephrine on cardiac preload, index, and preload dependency during septic shock.Design:Prospective interventional study.Setting:Medical Intensive Care Unit.Patients:We included 25 shock patients (62 ± 13 yrs old, Simplified Acute Physiology Scor

参考文章(35)
Thierry Pottecher, Sylvie Calvat, Hervé Dupont, Jacques Durand-Gasselin, Patrick Gerbeaux, SFAR/SRLF workgroup, Haemodynamic management of severe sepsis: recommendations of the French Intensive Care Societies (SFAR/SRLF) Consensus Conference, 13 October 2005, Paris, France Critical Care. ,vol. 10, pp. 311- 311 ,(2006) , 10.1186/CC4965
S Goldman, C Appleton, M Olajos, E Morkin, Alpha-1 adrenergic control of the venous circulation in intact dogs. Journal of Pharmacology and Experimental Therapeutics. ,vol. 233, pp. 729- 734 ,(1985)
David LeDoux, Mark E. Astiz, Charles M. Carpati, Eric C. Rackow, Effects of perfusion pressure on tissue perfusion in septic shock. Critical Care Medicine. ,vol. 28, pp. 2729- 2732 ,(2000) , 10.1097/00003246-200008000-00007
Xavier Monnet, Jean-Louis Teboul, Passive leg raising Intensive Care Medicine. ,vol. 34, pp. 659- 663 ,(2008) , 10.1007/S00134-008-0994-Y
Aurélie Bourgoin, Marc Leone, Anne Delmas, Franck Garnier, Jacques Albanèse, Claude Martin, Increasing mean arterial pressure in patients with septic shock: effects on oxygen variables and renal function. Critical Care Medicine. ,vol. 33, pp. 780- 786 ,(2005) , 10.1097/01.CCM.0000157788.20591.23
Edward J. Winslow, Henry S. Loeb, Shahbudin H. Rahimtoola, Savitri Kamath, Rolf M. Gunnar, Hemodynamic studies and results of therapy in 50 patients with bacteremic shock The American Journal of Medicine. ,vol. 54, pp. 421- 432 ,(1973) , 10.1016/0002-9343(73)90038-7
PARTHA DATTA, SHELDON MAGDER, Hemodynamic response to norepinephrine with and without inhibition of nitric oxide synthase in porcine endotoxemia. American Journal of Respiratory and Critical Care Medicine. ,vol. 160, pp. 1987- 1993 ,(1999) , 10.1164/AJRCCM.160.6.9808019
Xavier Monnet, David Osman, Christophe Ridel, Bouchra Lamia, Christian Richard, Jean-Louis Teboul, Predicting volume responsiveness by using the end-expiratory occlusion in mechanically ventilated intensive care unit patients Critical Care Medicine. ,vol. 37, pp. 951- 956 ,(2009) , 10.1097/CCM.0B013E3181968FE1
C. Martin, P. Saux, B. Eon, P. Aknin, F. Gouin, Septic shock: a goal-directed therapy using volume loading, dobutamine and/or norepinephrine Acta Anaesthesiologica Scandinavica. ,vol. 34, pp. 413- 417 ,(1990) , 10.1111/J.1399-6576.1990.TB03114.X