Superwetting and aptamer functionalized shrink-induced high surface area electrochemical sensors.

摘要: Electrochemical sensing is moving to the forefront of point-of-care and wearable molecular technologies due ability miniaturize required equipment, a critical advantage over optical methods in this field. sensors that employ roughness increase their microscopic surface area offer strategy combatting loss signal associated with macroscopic upon miniaturization. A simple, low-cost method creating such has emerged development shrink-induced high electrodes. Building on approach, we demonstrate here greater than 12-fold enhancement electrochemically active conventional electrodes equivalent on-chip footprint areas. This two-fold improvement previous performance obtained via creation superwetting condition facilitated by dissolvable polymer coating. As test bed illustrate utility further show electrochemical aptamer-based exhibit exceptional strength (signal-to-noise) excellent gain (relative change target binding) when deployed these shrink Indeed, observed 330% observe for kanamycin sensor 2-fold seen planar gold