Molecular Adaptation to Toxic Chemicals and Drugs

摘要: Publisher Summary This chapter discusses the molecular adaptation phenomena of host against toxic chemical (drug) insults. Molecular starts at level organism–environment relationship through a series biochemical processes. Nucleic acids and proteins have undergone, in phylogenetic descent, all pervasive continuous changes their primary structure. process informational macromolecules is basis as influenced by environmental factors.. Each organism orchestrates to adapt changing environment, which two most effective ones are (1) induced reactions (2) mutation. The also describes enzymatic adaptation. higher organisms appear developed class genes encoding various enzymes designed meet need for detoxication compounds that without physiological value. Such may be classified broadly into four types, occurring distinct phases: phase I-biotransformation, II-detoxification.