Knockdown of S100A11 expression suppresses ovarian cancer cell growth and invasion
作者： YOUQING LIU , XIAOBING HAN , BAOAN GAO
关键词: Cell growth 、 Small hairpin RNA 、 Biology 、 Immunology 、 Ovarian cancer 、 Oncogene 、 Cancer research 、 Cancer 、 Gene knockdown 、 Cell 、 Molecular medicine
摘要: As a member of the S100 protein family, S100A11 expression is often upregulated in human cancer tissues. Numerous studies have demonstrated that plays an important role progression cancer. However, function ovarian remains elusive. In present study, levels were found to be significantly increased cells. Subsequently, HO8910 cells was knocked down using short hairpin (sh)RNA order investigate biological effects on disease. The results knockdown by shRNA inhibited proliferation, anchorage-independent growth, invasion and migration addition, E-cadherin decreased Snail Collectively, these indicated able promote Therefore, may serve as potential molecular target for diagnosis treatment
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