A Trial Of A Group A Plus Group C Meningococcal Polysaccharide-Protein
作者： P. A. Twumasi , S. Kumah , A. Leach , T. J. D. O'Dempsey , S. J. Ceesay
关键词: Virology 、 Neisseria meningitidis 、 Group A 、 Immunogenicity 、 Conjugate vaccine 、 Immunology 、 Polysaccharide Vaccine 、 Antibody 、 Meningococcal disease 、 Vaccination 、 Biology
摘要: The safety and immunogenicity of a group A plus C meningococcal polysaccharide-CRM 197 conjugate vaccine was evaluated in 304 8- to 10-week-old Gambian infants. Infants were immunized with one, two, or three doses two polysaccharide vaccine. produced few systemic side effects, local reactions similar those by the Postvaccination antibody levels, measured ELISA, increased progressively after However, one dose ofconjugate given at age 6 months induced higher response than did 2 months. Two levels Thus, this new proved be safe immunogenic
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sci-hub.se 参考文章(20)
Gotschlich Ec, Boctar W, Amer A, el-Ghoroury Aa, Hablas R, Cvjetanović B, Sippel Je, Sanborn Wr, Rizk F, Wahdan Mh, el-Akkad Am, Triau R, Girgis Ni, A controlled field trial of a serogroup A meningococcal polysaccharide vaccine. Bulletin of The World Health Organization. ,vol. 48, pp. 667- 673 ,(1973)
Warren R. Sanborn, Claire V. Broome, Adamou A. Yada, Hien Giat, LeVan Giat, Michael A. Rugh, David W. Fraser, Jean Marie Zeltner, Epidemic group C meningococcal meningitis in Upper Volta, 1979. Bulletin of The World Health Organization. ,vol. 61, pp. 325- 330 ,(1983)
A. A. Idris, H. H. Erwa, L. Lapeyssonnie, W. R. Sanborn, M. A. Haseeb, J. E. Sippel, A serogroup A meningococcal polysaccharide vaccine: studies in the Sudan to combat cerebrospinal meningitis caused by Neisseria meningitidis group A. Bulletin of The World Health Organization. ,vol. 49, pp. 301- 305 ,(1973)
Vandepitte J, Andre Fe, Crooy Pj, Vimont-Vicary P, Roelants P, Bosmans E, Protective efficacy of a bivalent (A + C) meningococcal vaccine during a cerebrospinal meningitis epidemic in Rwanda. Annales de la Societe belge de medecine tropicale. ,vol. 60, pp. 297- 306 ,(1980)
Nancy Binkin, Jeffrey Band, Epidemic of meningococcal meningitis in Bamako, Mali: epidemiological features and analysis of vaccine efficacy. The Lancet. ,vol. 320, pp. 315- 318 ,(1982) , 10.1016/S0140-6736(82)90282-3
ArthurL Reingold, AllenW Hightower, GailA Bolan, EllenE Jones, Hilaire Tiendrebeogo, ClaireV Broome, GloriaW Ajello, Catherine Adamsbaum, Catherine Phillips, Adamou Yada, AGE-SPECIFIC DIFFERENCES IN DURATION OF CLINICAL PROTECTION AFTER VACCINATION WITH MENINGOCOCCAL POLYSACCHARIDE A VACCINE The Lancet. ,vol. 326, pp. 114- 118 ,(1985) , 10.1016/S0140-6736(85)90224-7
B.M Greenwood, S.S Wali, CONTROL OF MENINGOCOCCAL INFECTION IN THE AFRICAN MENINGITIS BELT BY SELECTIVE VACCINATION The Lancet. ,vol. 315, pp. 729- 732 ,(1980) , 10.1016/S0140-6736(80)91230-1
BO A. CLAESSON, RACHEL SCHNEERSON, TERESA LAGERGÅRD, BIRGER TROLLFORS, JOHN TARANGER, JAN JOHANSSON, DOLORES BRYLA, JOHN B. ROBBINS, Persistence of serum antibodies elicited by Haemophilus influenzae type b-tetanus toxoid conjugate vaccine in infants vaccinated at 3, 5 and 12 months of age. Pediatric Infectious Disease Journal. ,vol. 10, pp. 560- 563 ,(1991) , 10.1097/00006454-199108000-00002
Idris Mohammed, Karel Zaruba, CONTROL OF EPIDEMIC MENINGOCOCCAL MENINGITIS BY MASS VACCINATION The Lancet. ,vol. 318, pp. 80- 83 ,(1981) , 10.1016/S0140-6736(81)90423-2
B.M. Greenwood, H.C. Whittle, A.K. Bradley, M.T. Fayet, H.M. Gilles, The duration of the antibody response to meningococcal vaccination in an African village. Transactions of The Royal Society of Tropical Medicine and Hygiene. ,vol. 74, pp. 756- 760 ,(1980) , 10.1016/0035-9203(80)90195-9