Alterations in nicotinic α4β2 receptor binding in vascular dementia using 123I-5IA-85380 SPECT: Comparison with regional cerebral blood flow

摘要: Abstract Objective To investigate differences in distribution of α4β2 subtypes nicotinic acetylcholine receptors (nAChRs) using the ligand 123 I-5-Iodo-3-[2(S)-2-azetidinylmethoxy] pyridine (5IA-85380) and single photon emission computed tomography (SPECT) subjects with vascular dementia age-matched controls. I-5IA-85380 binding was compared to corresponding regional cerebral blood flow (rCBF) changes same subjects. Methods Thirty (14 16 controls) underwent rCBF ( 99m Tc-exametazime) SPECT scanning. Image analysis performed on voxel basis statistical parametric mapping (SPM2). Results Compared controls, reductions relative uptake were identified dorsal thalamus right caudate dementia. Increase scaled cuneus also demonstrated Perfusion deficits anterior cingulate apparent patient group did not appear be associated changes. Conclusions Reduced confined sub-cortical regions, unlike cortical previously described Alzheimer's disease. Elevation normalised could a compensatory response reduced cholinergic activity thalamus.