The role of fMRI in drug discovery

摘要: Pharmacological functional (phMRI) studies are making a significant contribution to our understanding of drug-effects on brain systems. fMRI has an additional make in the translation disease models and candidate compounds from preclinical clinical investigation early stages drug development. Here it can demonstrate proof-of-concept action small human cohort thus contribute substantially decision-making We review methods underlying pharmacological links that be made between animal investigations. discuss potential markers effect, experimental designs caveats interpreting hemodynamic data as reflective changes neuronal activity. Although there no current published examples applied novel compounds, we illustrate across range applications with specific reference processing pain analgesia. is developing meet neuroscientific challenges. Electrophysiological used corroborate effects measured hemodynamically fMRI. In future, likely extend examinations spinal cord into pharmacogenetics relate genetic polymorphisms differential responses drugs.