Design and Implementation of a Transmit/Receive Ultrasound Phased Array for Brain Applications

摘要: Focused ultrasound phased array systems have attracted increased attention for brain therapy applications. However, such currently lack a direct and real-time method to intraoperatively monitor pressure distribution securing treatment. This study proposes dual-mode system design support transmit/receive operations concurrent exposure backscattered focal beam reconstruction through spherically focused array. A 256-channel transmission was used transmit ultrasonic energy (full 256 channels), with an extended implementation of multiple-channel receiving function (up 64 channels) using the same coherent backscatter-received formation algorithm implemented map point spread (PSF) under free-field/transcranial environment setup, backscattering generated from strong scatterer (a reflector or microbubble-perfused tube) weakly scattered tissue-mimicking graphite phantom. Our results showed that PSF can be successfully reconstructed visualized in free-field conditions also transcranially following skull-induced aberration correction. In vivo experiments were conducted demonstrate its capability preoperatively semiquantitatively guide blood–brain barrier opening. The proposed may potential guidance intervention, facilitate therapeutic