Poly (ε-caprolactone) nanocapsules for oral delivery of raloxifene: process optimization by hybrid design approach,in vitroandin vivoevaluation
作者： N. Aditya , Punna Rao Ravi , Uday Sai Ranjan Avula , Rahul Vats
DOI: 10.3109/02652048.2014.885603
关键词: Materials science 、 Caprolactone 、 Bioavailability 、 Pharmacology 、 Raloxifene 、 In vitro 、 Plackett–Burman design 、 Nanocapsules 、 In vivo 、 Pharmacokinetics 、 Physical and Theoretical Chemistry 、 Colloid and Surface Chemistry 、 Organic chemistry 、 Bioengineering 、 Pharmaceutical Science
摘要: AbstractRaloxifene HCl (RLX), a selective oestrogen receptor modulator, has low oral bioavailability ( 80%). RLX-loaded nanocapsules showed 2.1-fold increase in compared to free RLX. IV pharmacokinetic studies indicated that RLX loaded into nanocapsule had significantly clearance comparison with Designed promise as delivery systems enhance and reducin...
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