The Gene in Cancer

摘要: It was through investigations of certain retroviruses that could transform cells the first knowledge gained role specific gene sequences in induction tumors and malignancies. Apparently, such cistrons, which are largely homologous to particular ones host, act concert with viral transcription-control elements lead tumor or neoplastic formation mammals experimental tissue cultures (R. Watson et al., 1982; Feramisco 1985; Van Beveren 1985). Although for obvious reasons studies have focused mainly on vertebrates, similar processes seem be active at times insects even yeasts, fungi, seed plants. At present time few normal functions been determined cellular counterparts cancer-producing, onc,genes, as they called (Vande Woude 1984). To distinguish between homologs, a v-or c-is prefixed abbreviation, v-onc c-fas, respectively. In some laboratories, c-onc genes referred proto-oncogenes, suggestive their being nonmalignant until recombined into genome (e.g., Katzen al.,1985; Shen is necessary point out not only capable inducing cell transformation, but structures themselves may do so when activated by various agents.