Enhancement of recombinant protein expression with copper
作者： Seyit Ozturk Sadettin , Veron Caple Matthew
DOI:
关键词: Cupric Ion 、 Coagulation 、 Copper 、 Cell 、 Recombinant DNA 、 Recombinant factor viii 、 Molecular biology 、 Protein expression 、 Cell culture 、 Biochemistry 、 Chemistry
摘要: The present invention provides a novel use of copper (cupric ion) for improved cell expression recombinant proteins, particularly coagulation proteins such as Factor VIII, B Domain Deleted IX and rFVII or rFVIIa. culture supplement results in higher productivity robustness the manufacturing process. This improvements product stability.
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