Organic Cation Transporters Are Determinants of Oxaliplatin Cytotoxicity
作者： Shuzhong Zhang , Katherine S. Lovejoy , James E. Shima , Leah L. Lagpacan , Yan Shu
DOI: 10.1158/0008-5472.CAN-06-0769
关键词: Transporter 、 Cytotoxicity 、 Carboplatin 、 Cell culture 、 Pharmacology 、 Oxaliplatin 、 Cisplatin 、 SLC47A1 、 Chemistry 、 Organic cation transport proteins 、 Cancer research 、 Oncology
摘要: Although the platinum-based anticancer drugs cisplatin, carboplatin, and oxaliplatin have similar DNA-binding properties, only oxaliplatin is active against colorectal tumors. The …
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