Progression of Aortic Calcification Is Associated With Metacarpal Bone Loss During Menopause A Population-Based Longitudinal Study

作者: A. Elisabeth Hak , Huibert A. P. Pols , Albert M. van Hemert , Albert Hofman , Jacqueline C. M. Witteman

DOI: 10.1161/01.ATV.20.8.1926

关键词: Bone densityMenopauseOsteoporosisVascular diseaseSurgeryCalcificationBone diseaseUrologyMedicineAbdominal aortaAorta

摘要: Abstract—Atherosclerosis and osteoporosis are major causes of morbidity mortality in postmenopausal women have been suggested to be associated. No study has examined whether progression atherosclerotic calcification is associated with bone loss. In the present study, we aortic calcification, diagnosed by radiographic detection calcified deposits abdominal aorta, relation metacarpal loss, as assessed radiogrammetry, during menopause. Initially premenopausal (n=236), aged 45 57 years at baseline, were followed for 9 years. We additionally cross-sectional association between extent mass density 720 women. Twenty-five percent going through menopause showed calcification. The average loss among was 3.2 mm2, their wa...

参考文章(54)
S. Phan, M. D. Rekhter, K. Zhang, A. S. Narayanan, M. A. Schork, D. Gordon, Type I collagen gene expression in human atherosclerosis. Localization to specific plaque regions. American Journal of Pathology. ,vol. 143, pp. 1634- 1648 ,(1993)
James C. Fleet, Janet M. Hock, Identification of osteocalcin mrna in nonosteoid tissue of rats and humans by reverse transcription—polymerase chain reaction Journal of Bone and Mineral Research. ,vol. 9, pp. 1565- 1573 ,(2009) , 10.1002/JBMR.5650091009
WS Browner, DG Seeley, SR Cummings, TM Vogt, Study of Osteoporotic Fractures Research Group, Non-trauma mortality in elderly women with low bone mineral density The Lancet. ,vol. 338, pp. 355- 358 ,(1991) , 10.1016/0140-6736(91)90489-C
W.S Browner, M.R Malinow, Homocyst(e)inaemia and bone density in elderly women. The Lancet. ,vol. 338, pp. 1470- ,(1991) , 10.1016/0140-6736(91)92782-W
JacquelineC.M. Witteman, FransJ. Kok, JanL.C.M. Van Saase, HansA. Valkenburg, AORTIC CALCIFICATION AS A PREDICTOR OF CARDIOVASCULAR MORTALITY The Lancet. ,vol. 328, pp. 1120- 1122 ,(1986) , 10.1016/S0140-6736(86)90530-1
Michiel L. Bots, Jacqueline C.M. Witteman, Diederick E. Grobbee, Carotid intima-media wall thickness in elderly women with and without atherosclerosis of the abdominal aorta. Atherosclerosis. ,vol. 102, pp. 99- 105 ,(1993) , 10.1016/0021-9150(93)90088-C
R. Jilka, G Hangoc, G Girasole, G Passeri, D. Williams, J. Abrams, B Boyce, H Broxmeyer, S. Manolagas, Increased osteoclast development after estrogen loss: mediation by interleukin-6 Science. ,vol. 257, pp. 88- 91 ,(1992) , 10.1126/SCIENCE.1621100
J. C. Witteman, D. E. Grobbee, F. J. Kok, A. Hofman, H. A. Valkenburg, Increased risk of atherosclerosis in women after the menopause. BMJ. ,vol. 298, pp. 642- 644 ,(1989) , 10.1136/BMJ.298.6674.642
J R Margolis, J T Chen, Y Kong, R H Peter, V S Behar, J A Kisslo, The diagnostic and prognostic significance of coronary artery calcification. A report of 800 cases. Radiology. ,vol. 137, pp. 609- 616 ,(1980) , 10.1148/RADIOLOGY.137.3.7444045
Marcia F. Kalin, Barnett Zumoff, Sex hormones and coronary disease: a review of the clinical studies. Steroids. ,vol. 55, pp. 330- 352 ,(1990) , 10.1016/0039-128X(90)90058-J