Flavonoids differentially modulate liver X receptors activity-Structure-function relationship analysis.

作者: Allan Fouache , Nada Zabaiou , Cyrille De Joussineau , Laurent Morel , Sandrine Silvente-Poirot

DOI: 10.1016/J.JSBMB.2019.03.028

关键词: Cell biologyReceptorOxysterolApigeninGalanginNuclear receptorMechanism of actionLiver X receptorNaringeninChemistry

摘要: … have hypothesized that flavonoids could regulate LXR pathways. For that purpose, we have selected quercetin (QUE), one of the major polyphenols within the flavonoid family, which is …

参考文章(46)
Narimane Segueni, Amar Zellagui, Fairouz Moussaoui, Mesbah Lahouel, Salah Rhouati, Flavonoids from Algerian propolis Arabian Journal of Chemistry. ,vol. 9, ,(2016) , 10.1016/J.ARABJC.2011.05.013
Bethany A. Janowski, Patricia J. Willy, Thota Rama Devi, J. R. Falck, David J. Mangelsdorf, An oxysterol signalling pathway mediated by the nuclear receptor LXRα Nature. ,vol. 383, pp. 728- 731 ,(1996) , 10.1038/383728A0
Ashley Stanley, Lumbani Yadav, Akulapalli Sudhakar, Ashok K. Varma, Rohan Patil, Suranjana Das, Optimized Hydrophobic Interactions and Hydrogen Bonding at the Target-Ligand Interface Leads the Pathways of Drug-Designing PLoS ONE. ,vol. 5, pp. e12029- ,(2010) , 10.1371/JOURNAL.PONE.0012029
Emi Kaneko, Morihiro Matsuda, Yukio Yamada, Yoji Tachibana, Iichiro Shimomura, Makoto Makishima, Induction of Intestinal ATP-binding Cassette Transporters by a Phytosterol-derived Liver X Receptor Agonist Journal of Biological Chemistry. ,vol. 278, pp. 36091- 36098 ,(2003) , 10.1074/JBC.M304153200
Yun Hu, Yaqi Yang, Yanjun Yu, Gesi Wen, Nana Shang, Wei Zhuang, Dihan Lu, Binhua Zhou, Baoxia Liang, Xin Yue, Feng Li, Jun Du, Xianzhang Bu, Synthesis and identification of new flavonoids targeting liver X receptor β involved pathway as potential facilitators of Aβ clearance with reduced lipid accumulation. Journal of Medicinal Chemistry. ,vol. 56, pp. 6033- 6053 ,(2013) , 10.1021/JM301913K
A J C Pommier, G Alves, E Viennois, S Bernard, Y Communal, B Sion, G Marceau, C Damon, K Mouzat, F Caira, S Baron, J M A Lobaccaro, Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells Oncogene. ,vol. 29, pp. 2712- 2723 ,(2010) , 10.1038/ONC.2010.30
Joyce J Repa, Guosheng Liang, Jiafu Ou, Yuriy Bashmakov, Jean-Marc A Lobaccaro, Iichiro Shimomura, Bei Shan, Michael S Brown, Joseph L Goldstein, David J Mangelsdorf, Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ Genes & Development. ,vol. 14, pp. 2819- 2830 ,(2000) , 10.1101/GAD.844900
Lihua Jin, Yong Li, Structural and functional insights into nuclear receptor signaling Advanced Drug Delivery Reviews. ,vol. 62, pp. 1218- 1226 ,(2010) , 10.1016/J.ADDR.2010.08.007
Aurélien J. C. Pommier, Julie Dufour, Georges Alves, Emilie Viennois, Hugues De Boussac, Amalia Trousson, David H. Volle, Françoise Caira, Pierre Val, Philippe Arnaud, Jean-Marc A. Lobaccaro, Silvère Baron, Liver X Receptors Protect from Development of Prostatic Intra-Epithelial Neoplasia in Mice PLoS Genetics. ,vol. 9, pp. e1003483- ,(2013) , 10.1371/JOURNAL.PGEN.1003483
Emilie Viennois, Kevin Mouzat, Julie Dufour, Laurent Morel, Jean-Marc Lobaccaro, Silvère Baron, Selective liver X receptor modulators (SLiMs): What use in human health? Molecular and Cellular Endocrinology. ,vol. 351, pp. 129- 141 ,(2012) , 10.1016/J.MCE.2011.08.036