Gene Silencing Quantitatively Controls the Function of a Developmental trans-Activator
作者： Anne S Hutchins , Alan C Mullen , Hubert W Lee , Kara J Sykes , Frances A High
DOI: 10.1016/S1097-2765(02)00564-6
关键词: Chromatin 、 Methyl-CpG-binding domain 、 Biology 、 Gene silencing 、 DNA 、 Molecular biology 、 Activator (genetics) 、 DNA methylation 、 Cell division 、 Epigenetics of physical exercise 、 Cell biology
摘要: … We found that the poorly differentiated Mbd2 −/− Th1 cells retained certain features of wild-type Th2 cells with respect to promoter inducibility. IL-4 synthesis in the mutant Th1 cells …
unirioja.es
elsevier.com
sci-hub.se 参考文章(61)
Fabio M.V. Rossi, Andrew M. Kringstein, Albert Spicher, Oivin M. Guicherit, Helen M. Blau, Transcriptional Control: Rheostat Converted to On/Off Switch Molecular Cell. ,vol. 6, pp. 723- 728 ,(2000) , 10.1016/S1097-2765(00)00070-8
M Yoshida, M Kijima, M Akita, T Beppu, Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. Journal of Biological Chemistry. ,vol. 265, pp. 17174- 17179 ,(1990) , 10.1016/S0021-9258(17)44885-X
Richard Festenstein, Soheila Sharghi-Namini, Margaret Fox, Kathleen Roderick, Mauro Tolaini, Trisha Norton, Alexander Saveliev, Dimitris Kioussis, Prim Singh, Heterochromatin protein 1 modifies mammalian PEV in a dose- and chromosomal-context-dependent manner. Nature Genetics. ,vol. 23, pp. 457- 461 ,(1999) , 10.1038/70579
Huck-Hui Ng, Yi Zhang, Brian Hendrich, Colin A. Johnson, Bryan M. Turner, Hediye Erdjument-Bromage, Paul Tempst, Danny Reinberg, Adrian Bird, MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. Nature Genetics. ,vol. 23, pp. 58- 61 ,(1999) , 10.1038/12659
Wolf Reik, Wendy Dean, Jorn Walter, Epigenetic Reprogramming in Mammalian Development Science. ,vol. 293, pp. 1089- 1093 ,(2001) , 10.1126/SCIENCE.1063443
Laurie H. Glimcher, Kenneth M. Murphy, Lineage commitment in the immune system: the T helper lymphocyte grows up Genes & Development. ,vol. 14, pp. 1693- 1711 ,(2000) , 10.1101/GAD.14.14.1693
Susanne J Szabo, Sean T Kim, Gina L Costa, Xiankui Zhang, C.Garrison Fathman, Laurie H Glimcher, A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell. ,vol. 100, pp. 655- 669 ,(2000) , 10.1016/S0092-8674(00)80702-3
Karen E Brown, Jonathan Baxter, Daniel Graf, Matthias Merkenschlager, Amanda G Fisher, Dynamic Repositioning of Genes in the Nucleus of Lymphocytes Preparing for Cell Division Molecular Cell. ,vol. 3, pp. 207- 217 ,(1999) , 10.1016/S1097-2765(00)80311-1
Lisa Ann Cirillo, Frank Robert Lin, Isabel Cuesta, Dara Friedman, Michal Jarnik, Kenneth S Zaret, Opening of Compacted Chromatin by Early Developmental Transcription Factors HNF3 (FoxA) and GATA-4 Molecular Cell. ,vol. 9, pp. 279- 289 ,(2002) , 10.1016/S1097-2765(02)00459-8
David J. Izon, Jennifer A. Punt, Lanwei Xu, Fredrick G. Karnell, David Allman, Peggy S. Myung, Nancy J. Boerth, John C. Pui, Gary A. Koretzky, Warren S. Pear, Notch1 Regulates Maturation of CD4+ and CD8+ Thymocytes by Modulating TCR Signal Strength Immunity. ,vol. 14, pp. 253- 264 ,(2001) , 10.1016/S1074-7613(01)00107-8