Molecular Mechanisms of Host Cell Invasion by Trypanosoma cruzi
作者： Conrad L. Epting , Bria M. Coates , David M. Engman
DOI: 10.1016/J.EXPPARA.2010.06.023
关键词: Chagas disease 、 Intracellular 、 Trypanosoma cruzi 、 Pathogen 、 Cell biology 、 Immune system 、 Biology 、 Innate immune system 、 Host cytoskeleton 、 Cell membrane
摘要: The protozoan parasite Trypanosoma cruzi, the etiologic agent of Chagas disease, is an obligate intracellular pathogen. Overlapping mechanisms ensure successful infection, yet relationship between these cellular events and clinical disease remains obscure. This review explores process cell invasion from perspective surface interactions, signaling, modulation host cytoskeleton endosomal compartment, innate immune response to infection.
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