Preparation of 131I–betulinic acid and its biodistribution in murine model of hepatocellular tumor
作者： Yu-Ping Xu , Min Yang , Dong-Hui Pan , Li-Zhen Wang
DOI: 10.1007/S10967-010-0925-6
关键词: Hydrogen peroxide 、 High-performance liquid chromatography 、 Pharmacology 、 Ethanol 、 Chemistry 、 Biodistribution 、 In vivo 、 Radiation therapy 、 Biochemistry 、 Betulinic acid 、 In vitro 、 Analytical chemistry 、 Spectroscopy 、 Public Health, Environmental and Occupational Health 、 Nuclear Energy and Engineering 、 Pollution 、 Health, Toxicology and Mutagenesis 、 Radiology Nuclear Medicine and imaging
摘要: The aim of this study was to examine the radioiodinating condition betulinic acid and understand possibility 131I–betulinic (131I–BA) as a potential tumor radiotherapy agent through in vitro uptake vivo biodistribution studies 131I–BA prepared by reaction with Na131I presence hydrogen peroxide, then purified HPLC. labeling yield about 80%, radiochemical purity greater than 95%. found be stable at 4 °C saline containing 1% ethanol. In showed that accumulated cancer cell lines (BEL-7402 NCI-H446) comparison free 131I−. KM mice bearing HepA stayed longer time tumors A significant differences were seen tumor/muscle ratio h postinjection between higher fraction can utilized for therapy dose will delivered per targeting event. is promising radiopharmaceutical nuclear medicine, especially hepatocellular targeted radionuclide brachytherapy.
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