Noninvasive scintigraphic detection of tumor with 99mTc-DTPA-deoxyglucose: an experimental study.
作者： Yue Chen , Qingfeng Xiong , Xiqun Yang , Zhanwen Huang , Yanling Zhao
DOI: 10.1089/CBR.2006.327
关键词:
摘要: Objectives: Glucosamine is a highly attractive scaffold for glucosyl ligand, and shows activity with glucose transporters hexokinase. In the study reported here, diethylenetriamine-pentaacetic acid– D -glucosamine (DTPA-DG) was synthesized by conjugating to DTPA, labeled technetium-99m (99mTc). We investigated 99mTc-DTPA–DG tumor detection. Methods: The biodistribution imaging of 99mTc-DTPA-DG in mammary tumor-bearing mice were compared those control group oleum terebinthinae (turpentine oil)-induced inflammation. Both groups given an intravenous injection 3.7 MBq/0.1 mL through tail vein. Results: accumulated tissue percentage 2.10 ± 0.02% injected dose per gram (%ID/g) at 2 hours after injection, versus accumulation 0.81 0.03%ID/g inflamed tissue. tumor-to-contralateral muscle ratio 5.01 1.02, while in...
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