作者: Bing-Jie Zhang , Xi-Feng Teng , Mei-Fen Bao , Xiu-Hong Zhong , Ling Ni
DOI: 10.1016/J.PHYTOCHEM.2014.12.025
关键词: Indole test 、 Stereochemistry 、 Cytotoxic T cell 、 Ic50 values 、 Monoterpenoid Indole Alkaloids 、 Officinalis 、 Cytotoxicity 、 HeLa 、 Tabernaemontana 、 Biology
摘要: Continued interest in cytotoxic alkaloids resulted the isolation of 37 including 29 known monoterpenoid indole from aerial parts Tabernaemontana officinalis. Of remaining 8 alkaloids, six were bisindole named taberdivarines A-F (1-6) and two monomers G H (7-8). Alkaloids 1 2 are voaphylline-vobasinyl type a structural previously unknown, while 3-6 exhibited cytotoxicity against three human cancer cell lines HeLa, MCF-7, SW480 with IC50 values ranging 1.42 to 11.35 mu M. (C) 2014 Elsevier Ltd. All rights reserved.