Circulating DNA and Next-Generation Sequencing

作者: Susanna Cooke , Peter Campbell

DOI: 10.1007/978-3-642-28160-0_12

关键词: Salvage therapyDisease burdenIntensive care medicineCancerMinimal residual diseaseSingle cell sequencingDiseaseCirculating DNAMedicineDNA sequencing

摘要: Personalising cancer medicine depends upon the implementation of personalised diagnostics and therapeutics. Detailed genomic screening is likely to play a central role in this. As range drugs other therapies for continues increase, there an increasingly urgent need sensitive specific measures disease burden guide treatment regimens. The ability quantify with high accuracy sensitivity patients would open many potential routes personalising therapeutic choices. For example, intensity therapy could be guided by amount at diagnosis; monitoring response allow extension period responders or early changeover nonresponders; prediction recurrence salvage instituted before complications relapse develop. detection tumour-specific rearrangements DNA free serum plasma may provide substantial advance solid tumours.

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