Circulating mutant DNA to assess tumor dynamics
作者： Frank Diehl , Kerstin Schmidt , Michael A Choti , Katharine Romans , Steven Goodman
DOI: 10.1038/NM.1789
关键词:
摘要: DNA containing somatic mutations is highly tumor specific and thus, in theory, can provide optimum markers. However, the number of circulating mutant gene fragments small compared to normal fragments, making it difficult detect quantify them with sensitivity required for meaningful clinical use. We apply a sensitive approach (ctDNA) body samples patients. Measurements ctDNA be used reliably monitor dynamics subjects cancer, especially those who are undergoing surgery or chemotherapy. This personalized genetic generally applied.
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