Quantitative and qualitative characterization of plasma DNA identifies primary and recurrent colorectal cancer
作者： M. Frattini , G. Gallino , S. Signoroni , D. Balestra , L. Lusa
DOI: 10.1016/J.CANLET.2008.03.021
关键词:
摘要: Because plasma DNA may be a useful tool for cancer detection, we screened primary tumors and related multiple samples at the time of surgery during follow-up period level as well K-Ras mutations p16INK4a promoter hypermethylation in colorectal patients. At surgery, levels were higher tumor patients than healthy donors, alterations detected 7 11 cancers respectively, all samples. During follow-up, decrease progressively but rapidly increased when relapse occurred, whereas only relapsed Therefore, combined quantitative qualitative analyses confirm presence cancer, define disease-free status indicate relapse.
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