Candidate Gene Association Mapping of Arabidopsis Flowering Time
作者： Ian M. Ehrenreich , Yoshie Hanzawa , Lucy Chou , Judith L. Roe , Paula X. Kover
DOI: 10.1534/GENETICS.109.105189
关键词: Association mapping 、 Population 、 Genetic linkage 、 Genetics 、 Gene mapping 、 Quantitative trait locus 、 Candidate gene 、 Arabidopsis thaliana 、 Biology 、 Single-nucleotide polymorphism
摘要: The pathways responsible for flowering time in Arabidopsis thaliana comprise one of the best characterized genetic networks plants. We harness this extensive molecular knowledge to identify potential quantitative trait genes (QTGs) through candidate gene association mapping using 51 loci. genotyped common single nucleotide polymorphisms (SNPs) at these 275 A. accessions that were also phenotyped and rosette leaf number long short days. Using structured techniques, we find haplotype-tagging SNPs 27 show significant associations various trait/environment combinations. After correction multiple testing, between 2 10 remain significantly associated with time, CO arguably possessing most promising associations. a subset an independent recombinant inbred line population derived from intercrossing 19 accessions. Approximately one-third outbred replicated both populations, including CO, FLC, VIN3, PHYD, GA1 loci, coding region deletions FRI gene. conservatively estimate ∼4–14% known may harbor alleles contribute natural variation life history trait.
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researchgate.net 参考文章(192)
Hyoun-Joung Kim, Youbong Hyun, Jin-Young Park, Mi-Jin Park, Mi-Kyung Park, Myoung Duck Kim, Hye-Joung Kim, Mi Hyun Lee, Jihyun Moon, Ilha Lee, Jungmook Kim, A genetic link between cold responses and flowering time through FVE in Arabidopsis thaliana Nature Genetics. ,vol. 36, pp. 167- 171 ,(2004) , 10.1038/NG1298
T Kania, D Russenberger, S Peng, K Apel, S Melzer, FPF1 promotes flowering in Arabidopsis. The Plant Cell. ,vol. 9, pp. 1327- 1338 ,(1997) , 10.1105/TPC.9.8.1327
J. H. Lee, S. J. Yoo, S. H. Park, I. Hwang, J. S. Lee, J. H. Ahn, Role of SVP in the control of flowering time by ambient temperature in Arabidopsis Genes & Development. ,vol. 21, pp. 397- 402 ,(2007) , 10.1101/GAD.1518407
Jihyun Moon, Sung-Suk Suh, Horim Lee, Kyu-Ri Choi, Choo Bong Hong, Nam-Chon Paek, Sang-Gu Kim, Ilha Lee, The SOC1 MADS‐box gene integrates vernalization and gibberellin signals for flowering in Arabidopsis Plant Journal. ,vol. 35, pp. 613- 623 ,(2003) , 10.1046/J.1365-313X.2003.01833.X
Marcelo J. Yanovsky, Steve A. Kay, Molecular basis of seasonal time measurement in Arabidopsis Nature. ,vol. 419, pp. 308- 312 ,(2002) , 10.1038/NATURE00996
D. A. William, Y. Su, M. R. Smith, M. Lu, D. A. Baldwin, D. Wagner, Genomic identification of direct target genes of LEAFY Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 1775- 1780 ,(2004) , 10.1073/PNAS.0307842100
Takato Imaizumi, Hien G. Tran, Trevor E. Swartz, Winslow R. Briggs, Steve A. Kay, FKF1 is essential for photoperiodic-specific light signalling in Arabidopsis Nature. ,vol. 426, pp. 302- 306 ,(2003) , 10.1038/NATURE02090
Keyan Zhao, María José Aranzana, Sung Kim, Clare Lister, Chikako Shindo, Chunlao Tang, Christopher Toomajian, Honggang Zheng, Caroline Dean, Paul Marjoram, Magnus Nordborg, An Arabidopsis Example of Association Mapping in Structured Samples PLOS Genetics. ,vol. 3, ,(2005) , 10.1371/JOURNAL.PGEN.0030004
Carlos Alonso-Blanco, Belen Mendez-Vigo, Maarten Koornneef, From phenotypic to molecular polymorphisms involved in naturally occurring variation of plant development. The International Journal of Developmental Biology. ,vol. 49, pp. 717- 732 ,(2005) , 10.1387/IJDB.051994CA
Chris A. Helliwell, Craig C. Wood, Masumi Robertson, W. James Peacock, Elizabeth S. Dennis, The Arabidopsis FLC protein interacts directly in vivo with SOC1 and FT chromatin and is part of a high-molecular-weight protein complex. Plant Journal. ,vol. 46, pp. 183- 192 ,(2006) , 10.1111/J.1365-313X.2006.02686.X