IL-12 and NK cells are required for antigen-specific adaptive immunity against malaria initiated by CD8+ T cells in the Plasmodium yoelii model.
作者： Denise L. Doolan , Stephen L. Hoffman
DOI:
关键词: Interleukin 21 、 Cytotoxic T cell 、 Biology 、 Immunology 、 Virology 、 Acquired immune system 、 Antigen-presenting cell 、 Natural killer T cell 、 Interleukin 12 、 T cell 、 IL-2 receptor
摘要: CD8+ T cells have been implicated as critical effector in protection against preerythrocytic stage malaria, including the potent protective immunity of mice and humans induced by immunization with radiation-attenuated Plasmodium spp. sporozoites. This is directed parasite developing within host hepatocyte for a number years has presumed to be mediated directly CTL or indirectly IFN-gamma released from cells. In this paper, BALB/c mice, we establish that after irradiated sporozoites DNA vaccines parasite-specific trigger novel mechanism adaptive dependent on cell- non-T cell-derived cytokines, particular IL-12, requires NK but not CD4+ The absolute requirement initiate such an mechanism, IL-12 vaccine-induced immunity, are unique underscore complexity immune responses protect malaria other intracellular pathogens.
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