Recent developments in malaria vaccinology.
作者： Benedict R. Halbroth , Simon J. Draper
DOI: 10.1016/BS.APAR.2015.03.001
关键词:
摘要: The development of a highly effective malaria vaccine remains key goal to aid in the control and eventual eradication this devastating parasitic disease. field has made huge strides recent years, with first-generation RTS,S showing modest efficacy Phase III clinical trial. updated 2030 Malaria Vaccine Technology Roadmap calls for second generation achieve 75% over two years both Plasmodium falciparum vivax, that can prevent transmission. Whole-parasite immunisation approaches combinations pre-erythrocytic subunit vaccines are now reporting high-level efficacy, whilst exciting new blood-stage transmission-blocking components entering development. multi-component multi-stage appears be realistic ambition. This review will cover these developments vaccinology.
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