Low expression of long noncoding RNA CASC2 indicates a poor prognosis and regulates cell proliferation in non-small cell lung cancer.
作者： Xuezhi He , Zhili Liu , Jun Su , Jinsong Yang , Dandan Yin
DOI: 10.1007/S13277-016-4787-6
关键词: Cancer research 、 Cell growth 、 Long non-coding RNA 、 Stage (cooking) 、 In vitro 、 Biology 、 Bioinformatics 、 Non small cell 、 In vivo 、 Lung cancer 、 A549 cell
摘要: Recently, long noncoding RNAs (lncRNAs) have been shown to important regulatory roles in human cancer biology. The aim of this study was evaluate the expression and biological role lncRNA CASC2 non-small cell lung (NSCLC). By bioinformatics analysis, we found that significantly decreased NSCLC. qRT-PCR performed investigate tumor tissues corresponding non-tumor NSCLC from 76 patients. lower remarkably correlated with advanced TNM stage size. Multivariate analyses served as an independent predictor for overall survival Moreover, overexpression inhibited proliferation both vitro vivo. In conclusion, our demonstrated is involved development progression shows may be a potential diagnostic target new therapies patients
springer.com
sci-hub.se 参考文章(29)
Sylvestre Le Moulec, Julien Hadoux, Éric Gontier, Cyrus Chargari, Carole Helissey, Virginie Lamand, Rachid Tanz, FranÇoise Farace, Lionel Vedrine, Gérald Bonardel, Jean-Charles Soria, Benjamin Besse, Combination of paclitaxel and bevacizumab in heavily pre-treated non-small-cell lung cancer (NSCLC) patients: a case series study on 15 Patients Bulletin Du Cancer. ,vol. 100, pp. 30- ,(2013) , 10.1684/BDC.2013.1864
P.M. Ellis, N. Coakley, R. Feld, S. Kuruvilla, Y.C. Ung, Use of the epidermal growth factor receptor inhibitors gefitinib, erlotinib, afatinib, dacomitinib, and icotinib in the treatment of non-small-cell lung cancer: a systematic review. Current Oncology. ,vol. 22, pp. 183- 215 ,(2015) , 10.3747/CO.22.2566
Gregory J. Riely, Helena A. Yu, EGFR: The Paradigm of an Oncogene-Driven Lung Cancer. Clinical Cancer Research. ,vol. 21, pp. 2221- 2226 ,(2015) , 10.1158/1078-0432.CCR-14-3154
Er-bao Zhang, Rong Kong, Dan-dan Yin, Liang-hui You, Ming Sun, Liang Han, Tong-peng Xu, Rui Xia, Jin-song Yang, Wei De, Jin fei Chen, Long noncoding RNA ANRIL indicates a poor prognosis of gastric cancer and promotes tumor growth by epigenetically silencing of miR-99a/miR-449a. Oncotarget. ,vol. 5, pp. 2276- 2292 ,(2014) , 10.18632/ONCOTARGET.1902
Fortunato Ciardiello, Assunta Sgambato, Francesca Casaluce, Cesare Gridelli, Paolo Maione, Antonio Rossi, Cetuximab in advanced non-small cell lung cancer (NSCLC): the showdown? Journal of Thoracic Disease. ,vol. 6, pp. 578- 580 ,(2014) , 10.3978/J.ISSN.2072-1439.2014.06.14
E-b Zhang, D-d Yin, M Sun, R Kong, X-h Liu, L-h You, L Han, R Xia, K-m Wang, J-s Yang, W De, Y-q Shu, Z-x Wang, P53-regulated long non-coding RNA TUG1 affects cell proliferation in human non-small cell lung cancer, partly through epigenetically regulating HOXB7 expression Cell Death and Disease. ,vol. 5, ,(2014) , 10.1038/CDDIS.2014.201
L Han, E-b Zhang, D-d Yin, R Kong, T-p Xu, W-m Chen, R Xia, Y-q Shu, W De, Low expression of long noncoding RNA PANDAR predicts a poor prognosis of non-small cell lung cancer and affects cell apoptosis by regulating Bcl-2 Cell Death and Disease. ,vol. 6, ,(2015) , 10.1038/CDDIS.2015.30
Tony Gutschner, Sven Diederichs, The hallmarks of cancer: a long non-coding RNA point of view. RNA Biology. ,vol. 9, pp. 703- 719 ,(2012) , 10.4161/RNA.20481
P. P. Amaral, M. E. Dinger, T. R. Mercer, J. S. Mattick, The eukaryotic genome as an RNA machine Science. ,vol. 319, pp. 1787- 1789 ,(2008) , 10.1126/SCIENCE.1155472
Mitchell Guttman, Ido Amit, Manuel Garber, Courtney French, Michael F. Lin, David Feldser, Maite Huarte, Or Zuk, Bryce W. Carey, John P. Cassady, Moran N. Cabili, Rudolf Jaenisch, Tarjei S. Mikkelsen, Tyler Jacks, Nir Hacohen, Bradley E. Bernstein, Manolis Kellis, Aviv Regev, John L. Rinn, Eric S. Lander, Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals Nature. ,vol. 458, pp. 223- 227 ,(2009) , 10.1038/NATURE07672