High expression of long non-coding RNA ATB indicates a poor prognosis and regulates cell proliferation and metastasis in non-small cell lung cancer
作者： L. Ke , S.-B. Xu , J. Wang , X.-L. Jiang , M.-Q. Xu
DOI: 10.1007/S12094-016-1572-3
关键词: A549 cell 、 Cancer research 、 Cell growth 、 Lung cancer 、 Metastasis 、 Cell migration 、 Cell culture 、 Pathology 、 Biology 、 Viability assay 、 Long non-coding RNA
摘要: Long non-coding RNAs (lncRNAs) have been demonstrated to act as a critical regulator in the processes of tumor biology. In this study, whether lncRNA-ATB is potential indicator for non-small cell lung cancer (NSCLC) was investigated and its biological function NSCLC also determined. The expression levels tissues lines were measured. A549 line explored investigate functions NSCLC. Real-time PCR results showed that up-regulated both lines. High tissue associated with larger size, lymph node metastasis, distant metastasis patients NSCLC, respectively. addition, high presented lower survival probability. vitro experiments down-regulation promoted apoptosis, whereas inhibited viability, migration, invasion. indicated poor prognosis led proliferation
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