The Function and Mechanism of Long Non-coding RNA-ATB in Cancers.
作者： Huizhong Xiao , Fuyou Zhang , Yifan Zou , Jianfa Li , Yuchen Liu
关键词: Colorectal cancer 、 microRNA 、 Breast cancer 、 Prostate cancer 、 Pancreatic cancer 、 Long non-coding RNA 、 Tumor progression 、 Biology 、 Cancer research 、 Cancer
摘要: Long non-coding RNAs (lncRNAs) are a class of transcriptional RNA molecules with length greater than 200 nucleotides that function as regulatory factors in many human diseases. Studies have shown lncRNAs involved multiple cellular processes, including proliferation, apoptosis, migration, and invasion. In this report, long RNA-ATB is overexpressed various tumor tissues cell lines was investigated. Recent evidence suggests ATB dysfunctional variety cancers, hepatocellular carcinoma, gastric cancer (GC), colorectal (CRC), breast (BC), prostate cancer, renal non-small lung (NSCLC), pancreatic osteosarcoma, glioma. The high expression associated clinicopathological features patients. addition, overexpression lncRNA-ATB can promote LncRNA-ATB induces epithelial-mesenchymal transition (EMT) by competitively binding to miRNAs, thus promoting progression. Biological functions mechanisms cancers discussed here, concluding may provide new biomarker for use diagnosis prognosis cancer.
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