A Long Non-coding RNA Activated by Transforming Growth Factor-β is an Independent Prognostic Marker of Gastric Cancer.
作者： Tomoko Saito , Junji Kurashige , Sho Nambara , Hisateru Komatsu , Hidenari Hirata
DOI: 10.1245/S10434-015-4554-8
关键词:
摘要: A recent study reported that long non-coding RNA activated by TGF-β (lncRNA-ATB) induced epithelial–mesenchymal transition (EMT) through the transforming growth factor-β (TGF-β)/miR-200s/ZEB axis in hepatocellular carcinoma. Herein, we focused on clinical significance of lncRNA-ATB gastric cancer (GC) patients. Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) was performed to examine expression lncRNA-ATB, miR-200b, and miR-200c GC tissues (n = 183). Patients were divided into high low groups using a cutoff lncRNA-ATB/GAPDH ≥0.60 or <0.60 determine clinicopathological GC. Moreover, evaluated TGF-β, miR-200s, ZEB1 cell lines qRT-PCR. treated recombinant TGF-β1 receptor inhibitor morphologic changes genetic alterations, such as levels, with respect EMT phenotype. The group experienced lower overall survival rate compared group, multivariate analysis indicated an independent prognostic factor (hazard ratio 3.50; 95 % CI 1.73–7.44; p = 0.0004). levels higher than group. Treatment resulted morphological changes, upregulation ZEB1, downregulation CDH1. SB431542 reduced expression. LncRNA-ATB plays important role promote invasion metastasis TGF-β/miR-200s/ZEB axis, resulting poor prognosis is novel biomarker lncRNA, indicative
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Samy Lamouille, Jian Xu, Rik Derynck, Molecular mechanisms of epithelial–mesenchymal transition Nature Reviews Molecular Cell Biology. ,vol. 15, pp. 178- 196 ,(2014) , 10.1038/NRM3758
Junji Kurashige, Hidenobu Kamohara, Masayuki Watanabe, Yukiharu Hiyoshi, Masaaki Iwatsuki, Youhei Tanaka, Koichi Kinoshita, Seiya Saito, Yoshifumi Baba, Hideo Baba, None, MicroRNA-200b regulates cell proliferation, invasion, and migration by directly targeting ZEB2 in gastric carcinoma. Annals of Surgical Oncology. ,vol. 19, pp. 656- 664 ,(2012) , 10.1245/S10434-012-2217-6
Mitchell Guttman, John L. Rinn, Modular regulatory principles of large non-coding RNAs Nature. ,vol. 482, pp. 339- 346 ,(2012) , 10.1038/NATURE10887
Philip A. Gregory, Andrew G. Bert, Emily L. Paterson, Simon C. Barry, Anna Tsykin, Gelareh Farshid, Mathew A. Vadas, Yeesim Khew-Goodall, Gregory J. Goodall, The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 Nature Cell Biology. ,vol. 10, pp. 593- 601 ,(2008) , 10.1038/NCB1722
Hanyin Cheng, Lina Zhang, David E Cogdell, Hong Zheng, Aaron J Schetter, Matti Nykter, Curtis C Harris, Kexin Chen, Stanley R Hamilton, Wei Zhang, None, Circulating Plasma MiR-141 Is a Novel Biomarker for Metastatic Colon Cancer and Predicts Poor Prognosis PLoS ONE. ,vol. 6, pp. e17745- ,(2011) , 10.1371/JOURNAL.PONE.0017745
Yongfu Shao, Huilin Chen, Xiaoming Jiang, Shengcan Chen, Peifei Li, Meng Ye, Qier Li, Weiliang Sun, Junming Guo, Low expression of lncRNA-HMlincRNA717 in human gastric cancer and its clinical significances Tumor Biology. ,vol. 35, pp. 9591- 9595 ,(2014) , 10.1007/S13277-014-2243-Z
Yukinori Kurokawa, Nariaki Matsuura, Ryohei Kawabata, Kazuhiro Nishikawa, Chikara Ebisui, Yuhki Yokoyama, Mohammed Nouri Shaker, Takuya Hamakawa, Tsuyoshi Takahashi, Shuji Takiguchi, Masaki Mori, Yuichiro Doki, Prognostic impact of major receptor tyrosine kinase expression in gastric cancer. Annals of Surgical Oncology. ,vol. 21, pp. 584- 590 ,(2014) , 10.1245/S10434-014-3690-X
Jean Paul Thiery, Epithelial-mesenchymal transitions in development and pathologies. Current Opinion in Cell Biology. ,vol. 15, pp. 740- 746 ,(2003) , 10.1016/J.CEB.2003.10.006
Imad J. Matouk, Nathan DeGroot, Shaul Mezan, Suhail Ayesh, Rasha Abu-lail, Abraham Hochberg, Eithan Galun, The H19 Non-Coding RNA Is Essential for Human Tumor Growth PLoS ONE. ,vol. 2, pp. e845- ,(2007) , 10.1371/JOURNAL.PONE.0000845
Ji-hang Yuan, Fu Yang, Fang Wang, Jin-zhao Ma, Ying-jun Guo, Qi-fei Tao, Feng Liu, Wei Pan, Tian-tian Wang, Chuan-chuan Zhou, Shao-bing Wang, Yu-zhao Wang, Yuan Yang, Ning Yang, Wei-ping Zhou, Guang-shun Yang, Shu-han Sun, A Long Noncoding RNA Activated by TGF-β Promotes the Invasion-Metastasis Cascade in Hepatocellular Carcinoma Cancer Cell. ,vol. 25, pp. 666- 681 ,(2014) , 10.1016/J.CCR.2014.03.010