High expression of long non-coding RNA lncRNA-ATB is correlated with metastases and promotes cell migration and invasion in renal cell carcinoma

摘要: Objective To investigate the expression pattern of a novel long non-coding ribonucleic acid activated by transforming growth factor β, in renal cell carcinoma tissues among patients with various clinicopathologic features and to detect possible role dysregulated RNA-ATB carcinoma. Methods The β cancer lines was evaluated quantitative real-time polymerase chain reaction. association analyzed. effects on proliferation, apoptosis, migration, invasion epithelial-to-mesenchymal transition were investigated loss-of-function approach. Results higher cells than adjacent non-tumor normal human proximal tubule epithelial HK-2. In addition, significantly metastasis. elevated associated tumor stages, histological grade, vascular invasion, lymph node metastasis distant Notably, we found that knockdown could (i) inhibit proliferation; (ii) trigger apoptosis; (iii) reduce program; (iv) suppress migration invasion. Conclusions Our data have shown actively functions as regulator during metastasis, which suggests may be potential prognostic biomarker therapeutic target for