The cutoff level of free/total prostate specific antigen (f/t PSA) ratios in the diagnosis of prostate cancer: a validation study on a Turkish patient population in different age categories.

摘要: We investigated an optimal cutoff level of free/total PSA ratios (f/t PSA) in predicting prostate cancer different age groups, focusing on the avoidance unnecessary biopsies. A total 4955 men were enrolled into study. Serum tPSA, fPSA, and f/t determined for study population. All males who had suspicious digital rectal examination tPSA > 4 ng/mL underwent transrectal ultrasonography-guided biopsy. Receiver operating characteristic (ROC) curves each group generated by plotting sensitivity versus 1-specificity ratio. The sensitivity, specificity, positive likelihood ratio (PLR), negative (NLR) obtained using various cutoffs groups. There 657 patients with a 4-10 ng/mL. According to specificity f/t% points be 10%, 15%, 10% 50-59 years, 60-69 >70 all ages categories, respectively, initial area under curve (AUC) value 0.81 (95% confidence level: 0.80-0.82) groups detecting cancer. has AUC 0.669 (0.632-0.705) among Ten percent highest PLR 30% lower NLR all-age categories. current shows that use levels should enhance screening decrease number age-related changes warrant further investigation large, multicentric, multinational population improve clinical cutoffs.