ECHO 9 virus infection and congenital abnormalities: a negative report.

摘要: Approximately 200,000 residents of Hennepin and Ramsey counties in Minnesota developed an aseptic meningitis syndrome during the summer fall 1957. One fourth patients had a maculopapular rash very similar to that rubella. The etiologic agent was found be ECHO virus type 9. This epidemic provided opportunity determine whether infection with this first trimester pregnancy could related appearance congenital defects such as occurs From March 3 through June 13, 1958, 10,109 liveborn infants 105 stillborn were delivered 12 Minneapolis 10 St. Paul hospitals serving these two counties. All mothers been exposed 1957 epidemic. Public health nurses interviewed 9,990 within few days after birth for detailed histories pregnancy. On basis interviews it judged 6.5% historic evidence 9 Serologic recent past present 19% 853 antibody titrations carried out on cord blood specimens from abnormals normals (controls). To discover anomalies not recognized at birth, follow-up 11 months later by public telephone some 9,600 mothers. There 356 major minor year life. An additional 63 hernias diagnosed total 419 live births study. rate 41.4 per 1,000 births, or 4.1%, is well rates reported other authors. A 39.6% 60.4% Of anomalies, 61% occurred males 39% females; 1.5% abnormalities 0.74% died result their stillbirths recorded, 10.4 births. compares 13.6 year. Among stillbirths, 11.4% comparison 10.95% statewide statistical analysis findings which titer distributions normal abnormal does justify conclusion mother increases incidence offspring. only exception generalization case skin abnormalities, where there suggestion association.