CXCL6 promotes non-small cell lung cancer cell survival and metastasis via down-regulation of miR-515-5p.
作者： Jun Li , Zhiyuan Tang , Haiying Wang , Wei Wu , Fengqiu Zhou
DOI: 10.1016/J.BIOPHA.2017.11.004
关键词: Lung cancer 、 CXCL6 、 Downregulation and upregulation 、 Suppressor 、 Biology 、 microRNA 、 Cancer research 、 Chemokine 、 Metastasis 、 Cell
摘要: Chemokine plays an important role in lung cancer and CXCL6 is one of chemokine, however, its effect on miRNAs profile roles non-small cell (NSCLC) not elucidated. This study purposed to explore the influence miRNA expression found that could reduce miR-515-5p NSCLC cells. MiR-515-5p cells inhibit survival metastasis. acted as a tumor suppressor by targeting These data highlighted novel molecular interaction between CXCL6. may constitute potential therapy target for NSCLC.
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