Transport of platelets induced by red blood cells based on mixture theory

作者: Wei-Tao Wu , Nadine Aubry , Mehrdad Massoudi , James F. Antaki

DOI: 10.1016/J.IJENGSCI.2017.05.002

关键词: PlateletBiophysicsThrombusBlood flowMixture theoryChemistry

摘要: Abstract The near-wall enrichment of platelets strongly influences thrombus formation in vivo and vitro . This paper develops a multi-constituent continuum approach to study this phenomenon. A mixture theory model is used describe the motion plasma red blood cells (RBCs) interactions between two components. transport developed influence RBCs field on platelets. flow rectangular micro-channel, sudden expansion channel containing micro crevices (representing practical problem encountered most blood-wetted devices). simulations show that concentration near walls about five times higher than centerline. It also noticed with crevices, large number accumulate deep part may serve as nidus for excessive occurring medical devices.

参考文章(67)
R. Zhao, J.N. Marhefka, J.F. Antaki, M.V. Kameneva, Drag-reducing polymers diminish near-wall concentration of platelets in microchannel blood flow. Biorheology. ,vol. 47, pp. 193- 203 ,(2010) , 10.3233/BIR-2010-0570
Wei-Tao Wu, Fang Yang, James F. Antaki, Nadine Aubry, Mehrdad Massoudi, Study of blood flow in several benchmark micro-channels using a two-fluid approach International Journal of Engineering Science. ,vol. 95, pp. 49- 59 ,(2015) , 10.1016/J.IJENGSCI.2015.06.004
M.J. Watach, H.S. Borovetz, M.V. Kameneva, K.O. Garrett, Red blood cell aging and risk of cardiovascular diseases Clinical Hemorheology and Microcirculation. ,vol. 18, pp. 67- 74 ,(1998)
Frédéric Frank Weller, Platelet deposition in non-parallel flow: influence of shear stress and changes in surface reactivity. Journal of Mathematical Biology. ,vol. 57, pp. 333- 359 ,(2008) , 10.1007/S00285-008-0163-5
I. H. Jaffer, J. C. Fredenburgh, J. Hirsh, J. I. Weitz, Medical device-induced thrombosis: what causes it and how can we prevent it? Journal of Thrombosis and Haemostasis. ,vol. 13, ,(2015) , 10.1111/JTH.12961
H. Bäumler, H. Kiesewetter, E. Donath, B. Neu, Basic phenomena of red blood cell rouleaux formation. Biorheology. ,vol. 36, pp. 439- 442 ,(1999)
James F. Antaki, Marina V. Kameneva, Rui Zhao, Investigation of platelet margination phenomena at elevated shear stress. Biorheology. ,vol. 44, pp. 161- 177 ,(2007)
Mehrdad Massoudi, Constitutive relations for the interaction force in multicomponent particulate flows International Journal of Non-linear Mechanics. ,vol. 38, pp. 313- 336 ,(2003) , 10.1016/S0020-7462(01)00064-6