Combining Ellagic Acid with Temozolomide Mediates the Cadherin Switch and Angiogenesis in a Glioblastoma Model
作者： Abdurrahman Çetin , Burcu Biltekin
DOI: 10.1016/J.WNEU.2019.08.228
关键词: Cadherin 、 Cancer research 、 Cell growth 、 Medicine 、 Immunohistochemistry 、 Angiogenesis 、 Messenger RNA 、 Ellagic acid 、 Temozolomide 、 Vascular endothelial growth factor 、 Surgery 、 Clinical neurology
摘要: Objective We aimed to evaluate the combined effect of ellagic acid (EA) and temozolomide (TEM) on cadherin switch angiogenesis in C6 glioma cell line. Methods A total 100 μM EA TEM were applied rat cells for 24, 48, 72 hours. Cell proliferation was detected by 5-bromo-2′-deoxyuridine immunohistochemistry. The messenger RNA protein levels E-cadherin, N-cadherin, vascular endothelial growth factor (VEGF) determined real-time polymerase chain reaction their immunohistochemistry, respectively, subsequent treatment with TEM. Results combination conspicuously reduced viability at all incubation times (P Conclusions successful therapeutic efficacy is suggested probably inhibiting angiogenesis.
elsevier.com
sci-hub.se 参考文章(38)
Bao-Hui Liu, Ling-Min Shao, Qian-Xue Chen, Ting-Feng Wu, Ji-Qiang Li, Wei Yi, Qian Yang, Peng Wu, Ji-An Yang, Puerarin inhibits proliferation and induces apoptosis in human glioblastoma cell lines. International Journal of Clinical and Experimental Medicine. ,vol. 8, pp. 10132- 10142 ,(2015)
Masabumi Shibuya, Brain angiogenesis in developmental and pathological processes: therapeutic aspects of vascular endothelial growth factor FEBS Journal. ,vol. 276, pp. 4636- 4643 ,(2009) , 10.1111/J.1742-4658.2009.07175.X
Rong Zhang, Ryuta Saito, Ichiyo Shibahara, Shinichiro Sugiyama, Masayuki Kanamori, Yukihiko Sonoda, Teiji Tominaga, Temozolomide reverses doxorubicin resistance by inhibiting P-glycoprotein in malignant glioma cells. Journal of Neuro-oncology. ,vol. 126, pp. 235- 242 ,(2016) , 10.1007/S11060-015-1968-X
Bhagavathi A. Narayanan, Otto Geoffroy, Mark C. Willingham, Gian G. Re, Daniel W. Nixon, p53/p21(WAF1/CIP1) expression and its possible role in G1 arrest and apoptosis in ellagic acid treated cancer cells. Cancer Letters. ,vol. 136, pp. 215- 221 ,(1999) , 10.1016/S0304-3835(98)00323-1
Ulf D. Kahlert, Donata Maciaczyk, Soroush Doostkam, Brent A. Orr, Brian Simons, Tomasz Bogiel, Thomas Reithmeier, Marco Prinz, Jörg Schubert, Gabriele Niedermann, Thomas Brabletz, Charles G. Eberhart, Guido Nikkhah, Jaroslaw Maciaczyk, Activation of canonical WNT/β-catenin signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-to-mesenchymal transition Cancer Letters. ,vol. 325, pp. 42- 53 ,(2012) , 10.1016/J.CANLET.2012.05.024
Alex Tobias, Atique Ahmed, Kyung-Sub Moon, Maciej S Lesniak, The art of gene therapy for glioma: a review of the challenging road to the bedside Journal of Neurology, Neurosurgery, and Psychiatry. ,vol. 84, pp. 213- 222 ,(2013) , 10.1136/JNNP-2012-302946
Mouad Edderkaoui, Irina Odinokova, Izumi Ohno, Ilya Gukovsky, Vay Liang W Go, Stephen J Pandol, Anna S Gukovskaya, None, Ellagic acid induces apoptosis through inhibition of nuclear factor κB in pancreatic cancer cells World Journal of Gastroenterology. ,vol. 14, pp. 3672- 3680 ,(2008) , 10.3748/WJG.14.3672
Krishna P.L. Bhat, Veerakumar Balasubramaniyan, Brian Vaillant, Ravesanker Ezhilarasan, Karlijn Hummelink, Faith Hollingsworth, Khalida Wani, Lindsey Heathcock, Johanna D. James, Lindsey D. Goodman, Siobhan Conroy, Lihong Long, Nina Lelic, Suzhen Wang, Joy Gumin, Divya Raj, Yoshinori Kodama, Aditya Raghunathan, Adriana Olar, Kaushal Joshi, Christopher E. Pelloski, Amy Heimberger, Se Hoon Kim, Daniel P. Cahill, Ganesh Rao, Wilfred F.A. Den Dunnen, Hendrikus W.G.M. Boddeke, Heidi S. Phillips, Ichiro Nakano, Frederick F. Lang, Howard Colman, Erik P. Sulman, Kenneth Aldape, Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma Cancer Cell. ,vol. 24, pp. 331- 346 ,(2013) , 10.1016/J.CCR.2013.08.001
Hui-Wen Lo, EGFR-Targeted Therapy in Malignant Glioma: Novel Aspects and Mechanisms of Drug Resistance Current Molecular Pharmacology. ,vol. 3, pp. 37- 52 ,(2010) , 10.2174/1874467211003010037
Dae-Hee Lee, Dong-Wook Kim, Chang-Hwa Jung, Yong J. Lee, Daeho Park, Gingerol sensitizes TRAIL-induced apoptotic cell death of glioblastoma cells Toxicology and Applied Pharmacology. ,vol. 279, pp. 253- 265 ,(2014) , 10.1016/J.TAAP.2014.06.030