Bioavailability, pharmacokinetics and residues of chloramphenicol in the chicken*

摘要: The pharmacokinetic properties of chloramphenicol were determined in broiler chickens after two single oral doses (30 and 50 mg/kg body weight) a intravenous (i.v.) dose weight). After i.v. administration, the plasma concentration-time graph was characteristic two-compartment open model. administration mg/kg), absorbed rapidly (time to maximal concentration 0.72 or 0.60 h) eliminated with mean half-life (t1/2 beta) 6.87 7.41 h, respectively. bioavailability 29% at 30 38% chloramphenicol. Concentrations greater than 5 micrograms/ml achieved 15 min persisted up 2 4 h post-administration, Statistically significant differences between routes found for variables, half-lives both distribution elimination phases alpha, t1/2 apparent volume [Vd(area)]. beta 5.23 h. Chloramphenicol extensively metabolized into dehydrochloramphenicol (DH-CAP), nitrophenylaminopropanedione (NPAP) nitroso-chloramphenicol (NO-CAP) derivatives. Residues (CAP) three metabolites DH-CAP, NPAP NO-CAP kidney, liver muscle measured that received an once daily days. results indicate CAP DH-CAP residues cleared slowly below detection limit 0.005 microgram/ml within 12 days dosing. However, time slaughter (12 days), detected tissue.