Tiotropium containing hfc solution formulations

作者: Christel Schmelzer , Sabine Six , Friedrich Schmidt

DOI:

关键词: Aerosol SolutionSalt (chemistry)DecompositionOrganic compoundChemistryOrganic chemistryHydrofluorocarbonOrganic acidTiotropium bromide

摘要: This invention relates to tiotropium containing stable pharmaceutical solution formulations suitable for aerosol administration. More particularly, this administration wherein either an inorganic acid or organic is added the formulation which contains a salt, preferably bromide in with environmentally safe hydrofluorocarbon (HFC) as propellant, together compound cosolvent. The provides stability against degradation decomposition of medicament resulting largely from interaction cosolvent and/or water present formulation.

参考文章(17)
Michael Paul Pieper, Michel Pairet, Christopher John Montague Meade, Pharmaceutical compositions based on anticholinergics and dopamine agonists ,(2001)
George Martin Benedikt, Ratnam Sooriyakumaran, Richard Vicari, Robert David Allen, Thomas Wallow, Saikumar Jayaraman, Larry Funderburk Rhodes, Richard Anthony DiPietro, Modified polycyclic polymers ,(1999)
Hagen Graebner, Michael Trunk, Michael Walz, Konrad Schindler, Helmut Bender, Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament ,(2003)
Karoline Bechtold-Peters, Georg Boeck, Michael Walz, Rolf Doerr, Inhalable powder containing tiotropium ,(2001)
Michael Trunk, Peter Specht, Christian Kulinna, Manfred Graulich, Peter Sieger, Helmut Meissner, Andreas Mathes, Rolf Banholzer, Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions ,(2003)
Karoline Bechtold-Peters, Michael Trunk, Dieter Hochrainer, Michael Walz, Capsules containing inhalable tiotropium ,(2002)
Barbara Niklaus-Humke, Karin Drechsel, Christel Schmelzer, Petra Barth, Aerosol formulation for inhalation containing a tiotropium salt ,(2003)