作者: Christel Schmelzer , Sabine Six , Friedrich Schmidt
DOI:
关键词: Aerosol Solution 、 Salt (chemistry) 、 Decomposition 、 Organic compound 、 Chemistry 、 Organic chemistry 、 Hydrofluorocarbon 、 Organic acid 、 Tiotropium bromide
摘要: This invention relates to tiotropium containing stable pharmaceutical solution formulations suitable for aerosol administration. More particularly, this administration wherein either an inorganic acid or organic is added the formulation which contains a salt, preferably bromide in with environmentally safe hydrofluorocarbon (HFC) as propellant, together compound cosolvent. The provides stability against degradation decomposition of medicament resulting largely from interaction cosolvent and/or water present formulation.