Novel form of tiotropium bromide and process for preparation thereof
作者： Francesca Scarpitta , Alexandr Jegorov , Alessandro Pontiroli , Nicola Diulgheroff , Adrienne Kovacsne-Mezei
DOI:
关键词: Combinatorial chemistry 、 Excipient 、 Chemistry 、 Pulmonary disease 、 Tiotropium bromide 、 Inorganic chemistry 、 Powder xrd 、 Crystal
摘要: PROBLEM TO BE SOLVED: To provide: novel crystal forms of tiotropium bromide, which are anticholinergics having specificity for muscarinic receptors and therapeutic agents the treatment asthma or chronic obstructive pulmonary disease; a process preparation forms; pharmaceutical formulations that contains forms.SOLUTION: This invention relates to: crystalline n-propanol solvate characterized by powder XRD pattern peaks at about 20.9, 21.1, 21.4 34.4±0.2° 2θ; preparing forming solution bromide in n-propanol, cooling to temperature 55-25°C form suspension; including an excipient pharmaceutically acceptable form.
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