Protein digestion and absorption in human small intestine.

摘要: Abstract The extent of digestion and absorption bovine serum albumin (BSA) a mixed meal was quantitatively examined in 6 healthy volunteers by means 5-lumen intestinal tube with perfused segments the proximal jejunum terminal ileum nonperfused sampling site ileum. At all times throughout 4-hr postprandial test periods, ratio protein to polyethylene glycol (PEG) marker jejunal samples approximately 40% PEG meal, indicating and/or 60% at this level. In ileum, less than 1% original meal. About 0.5 g passed through during period. A band electrophoretically coincident BSA on SDS-polyacrylamide gels detected from study, but not found ileal samples. amino acids oligopeptides constant small intestine. 200 mg free acid or oligopeptide nitrogen into colon 4 hr after ingestion. Trypsin concentration similar ileum; however, when corrected for reduction intraluminal volume it 8% activity jejunum. This study indicates that quantitative protein, BSA, is complete time an ingested has traversed total intestine, important completion process.